Patents can provide valuable economic and commercial benefits to patent holders. However, defending against infringement often hinges on the strength of the patentee's evidence supporting the patented invention. Laboratory notebooks play a significant role in these litigations, so one must prepare every notebook as though it were the key to winning that multi-billion dollar verdict. To ensure that any notebook, if called upon, will compel a judge or jury to view it as authoritative supporting evidence, consider the following guidelines: